The author concludes that objective methods for measuring joint disease symptoms, mobility, and pain using force plate gait analysis, accelerometers, and validated pain scales need to be established and that effective glucosamine and chondroitin dosing needs to be determined using dogs as the study subjects, as canine dosing is currently extrapolated from studies conducted in other species and therefore suboptimal. Similarly, the McKenzie (2010) commentary concludes that clinical trial evidence is severely limited. The author calls for veterinarians to translate the uncertainty around the usefulness of glucosamine and chondroitin therapy when discussing this treatment option with dog owners. McKenzie (2010) points out that there is a lack of literature addressing the use of glucosamine and chondroitin as an adjunct to NSAID therapy.
Can Dogs Take Human Glucosamine Chondroitin Arthritis Supplements
The Moreau et al. (2003) trial had several strengths. The study was double-blinded, prospective and subjects were randomized to treatment groups. Additionally, the authors claimed that mean age, weight, affected limb GRF values, radiographic scores, and subjective scores of the dogs in the four study arms were all similar at baseline, although data to support this claim was not provided. Weaknesses of the trial included that glucosamine and chondroitin doses are much lower in comparison to other clinical trials and the treatment regimens differed between study arms.
Glucosamine Chondroitin Dosage for Dogs - Dog Chondroitin
Investigators in the McCarthy et al. (2007) group conducted a prospective, randomized, double-blinded study that included 42 client-owned dogs, with 35 completing the trial. The dogs could be of any breed or sex, presenting with clinical signs of chronic lameness, stiffness, joint pain, and radiological evidence of osteoarthritis of the hips and/or elbows. The trial consisted of two arms in which the subjects received either: 1) glucosamine HCl, chondroitin sulfate, N-acetyl-D-glucosamine, ascorbic acid, and zinc sulfate or 2) carprofen. For complete dosing and titration schedules, please see . The primary outcome of efficacy in the treatment of osteoarthritis was determined through subjective veterinarian assessment at 0, 14, 42, 70 and 98 days of treatment.
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